Commensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma

Commensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma

Glaucoma is the most prevalent neurodegenerative disease and a leading cause of blindness worldwide. The mechanisms causing glaucomatous neurodegeneration are not fully understood. Here we show, using mice deficient in T and/or B cells and adoptive cell transfer, that transient elevation of intraocu...

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Main Authors: Chen, Huihui (Author), Cho, Kin-Sang (Author), Vu, T. H. Khanh (Author), Chen, Guochun (Author), Mathew, Rose (Author), McHam, M. Lisa (Author), Fazelat, Ahad (Author), Lashkari, Kameran (Author), AU, Ngan Pan Bennett (Author), TSE, Joyce Ka Yu (Author), Li, Yingqian (Author), Yu, Honghua (Author), Yang, Lanbo (Author), Stein-Streilein, Joan (Author), Ma, Chi Him Eddie (Author), Woolf, Clifford J. (Author), Jager, Martine J. (Author), Chen, Jianzhu (Author), Chen, Dong F. (Author), Shen, Chase (Contributor), Kaur, Mandeep (Contributor), Fox, James G (Contributor), Whary, Mark T. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Division of Comparative Medicine (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Whary, Mark T (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2018-09-07T15:51:50Z.
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