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01482 am a22002173u 4500 |
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117698 |
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|a dc
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|a Hong, Jiyoung A
|e author
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|a Massachusetts Institute of Technology. Department of Biological Engineering
|e contributor
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|a Koch Institute for Integrative Cancer Research at MIT
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|a Koehler, Angela Nicole
|e contributor
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|a Neel, Dylan V
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|a Wassaf, Dina
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|a Caballero, Francisco
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|a Koehler, Angela Nicole
|e author
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|a Recent discoveries and applications involving small-molecule microarrays
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|b Elsevier BV,
|c 2018-09-11T13:50:30Z.
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|z Get fulltext
|u http://hdl.handle.net/1721.1/117698
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|a High-throughput and unbiased binding assays have proven useful in probe discovery for a myriad of biomolecules, including targets of unknown structure or function and historically challenging target classes. Over the past decade, a number of novel formats for executing large-scale binding assays have been developed and used successfully in probe discovery campaigns. Here we review the use of one such format, the small-molecule microarray (SMM), as a tool for discovering protein-small molecule interactions. This review will briefly highlight selected recent probe discoveries using SMMs as well as novel uses of SMMs in profiling applications. © 2013 Elsevier Ltd.
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|a Article
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|t Current Opinion in Chemical Biology
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