Epigenetic Modulation Using Small Molecules - Targeting Histone Acetyltransferases in Disease

by Richters, Andre, Koehler, Angela Nicole
Published 2018

Transcription Factor Inhibition: Lessons Learned and Emerging Targets

by Chen, Andrew, Koehler, Angela Nicole
Published 2020

A Novel Small Molecule Activator of Nuclear Receptor SHP Inhibits HCC Cell Migration via Suppressing Ccl2

by Yang, Zhihong, Koehler, Angela Nicole, Wang, Li
Published 2020

Diversity-Oriented Synthesis as a Strategy for Fragment Evolution against GSK3β

by Zhong, Cheng, Ramek, Alexander, Koehler, Angela Nicole
Published 2020

Probing Small-Molecule Microarrays with Tagged Proteins in Cell Lysates

by Pop, Marius S., Wassaf, Dina, Koehler, Angela Nicole
Published 2016

Advances in discovering small molecules to probe protein function in a systems context

by Doyle, Shelby Kathleen, Pop, Marius S, Evans, Helen L, Koehler, Angela Nicole
Published 2017

Recent discoveries and applications involving small-molecule microarrays

by Hong, Jiyoung A, Neel, Dylan V, Wassaf, Dina, Caballero, Francisco, Koehler, Angela Nicole
Published 2018

Quantifying structure and performance diversity for sets of small molecules comprising small-molecule screening collections

by Wilson, J. A., Dancik, V., Muller, S., Wagner, B. K., Schreiber, S. L., Clemons, Paul A, Carrinski, Hyman, Koehler, Angela Nicole
Published 2018

Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles

by Clemons, P. A., Bodycombe, N. E., Carrinski, H. A., Wilson, J. A., Wagner, B. K., Schreiber, S. L., Shamji, Alykhan, Koehler, Angela Nicole
Published 2018

Chemical perturbation of an intrinsically disordered region of TFIID distinguishes two modes of transcription initiation

by Zhang, Zhengjian, Boskovic, Zarko, Hu, Wenxin, Inouye, Carla, Kim, Han-Je, Tjian, Robert, Hussain, Mahmud M., Abole, A. Katherine, Doud, Mary K., Lewis, Timothy A., Koehler, Angela Nicole, Schreiber, Stuart L.
Published 2015

A Small Molecule That Binds and Inhibits the ETV1 Transcription Factor Oncoprotein

by Pop, Marius S., Stransky, Nicolas, Garvie, Colin W., Theurillat, Jean-Philippe, Hartman, Emily C., Lewis, Timothy A., Zhong, Cheng, Culyba, Elizabeth K., Lin, Fallon, Daniels, Douglas S., Pagliarini, Raymond, Ronco, Lucienne, Koehler, Angela Nicole, Garraway, Levi A.
Published 2015

Disrupted in Schizophrenia 1 Regulates Neuronal Progenitor Proliferation via Modulation of GSK3β/β-Catenin Signaling

by Mao, Yingwei, Ge, Xuecai, Frank, Christopher Lee, Madison, Jon M., Koehler, Angela Nicole, Doud, Mary Kathryn, Tassa, Carlos, Berry, Erin M., Soda, Takahiro, Singh, Karun K., Biechele, Travis, Petryshen, Tracey L., Moon, Randall T., Haggarty, Stephen J., Tsai, Li-Huei
Published 2015

Identifying the proteins to which small-molecule probes and drugs bind in cells

by Ong, Shao-En, Schenone, Monica, Margolin, Adam A., Li, Xiaoyu, Do, Kathy, Doud, Mary Kathryn, Mani, D. R., Kuai, Letian, Wang, Xiang, Wood, John L., Tolliday, Nicola J., Koehler, Angela Nicole, Marcaurelle, Lisa A., Golub, Todd R., Gould, Robert J., Schreiber, Stuart L., Carr, Steven A.
Published 2009

Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics

by de Waal, Luc, Lewis, Timothy A, Rees, Matthew G, Tsherniak, Aviad, Wu, Xiaoyun, Choi, Peter S, Gechijian, Lara, Hartigan, Christina, Faloon, Patrick W, Hickey, Mark J, Tolliday, Nicola, Carr, Steven A, Clemons, Paul A, Munoz, Benito, Wagner, Bridget K, Shamji, Alykhan F, Schenone, Monica, Burgin, Alex B, Schreiber, Stuart L, Greulich, Heidi, Meyerson, Matthew, Koehler, Angela Nicole
Published 2017

Stabilization of the Max Homodimer with a Small Molecule Attenuates Myc-Driven Transcription

by Struntz, Nicholas B., Chen, Andrew I, Deutzmann, Anja, Wilson, Robert M., Stefan, Eric, Evans, Helen L, Ramirez, Maricela A., Liang, Tong, Caballero, Francisco, Wildschut, Mattheus H.E, Neel, Dylan V, Freeman, David B., Pop, Marius S, McConkey, Marie, Muller, Sandrine, Curtin, Brice Harrison, Tseng, Hanna, Frombach, Kristen R., Butty, Vincent L G, Levine, Stuart S., Feau, Clementine, Elmiligy, Sarah, Hong, Jiyoung A., Lewis, Timothy A., Vetere, Amedeo, Clemons, Paul A., Malstrom, Scott E., Ebert, Benjamin L., Lin, Charles Y., Felsher, Dean W., Koehler, Angela Nicole
Published 2020