Cancer Vulnerabilities Unveiled by Genomic Loss

by Nijhawan, Deepak, Zack, Travis I, Ren, Yin, Strickland, Matthew R, Lamothe, Rebecca, Schumacher, Steven E, Tsherniak, Aviad, Besche, Henrike C, Rosenbluh, Joseph, Shehata, Shyemaa, Cowley, Glenn S., Weir, Barbara A, Goldberg, Alfred L, Mesirov, Jill P., Root, David E, Beroukhim, Rameen, Hahn, William C., Bhatia, Sangeeta N
Published 2014

GeNets: a unified web platform for network-based genomic analyses

by Li, Taibo, Kim, April, Rosenbluh, Joseph, Horn, Heiko, Greenfeld, Liraz, An, David, Zimmer, Andrew, Liberzon, Arthur, Bistline, Jon, Natoli, Ted, Li, Yang, Tsherniak, Aviad, Narayan, Rajiv, Subramanian, Aravind, Liefeld, Ted, Wong, Bang, Thompson, Dawn, Calvo, Sarah, Carr, Steve, Boehm, Jesse, Jaffe, Jake, Mesirov, Jill, Hacohen, Nir, Regev, Aviv, Lage, Kasper
Published 2018

PIK3CA mutant tumors depend on oxoglutarate dehydrogenase

by Ilic, Nina, Birsoy, Kıvanç, Aguirre, Andrew J., Singh, Shambhavi, Moody, Susan E., DeAngelo, Joseph D., Spardy, Nicole A., Freinkman, Elizaveta, Weir, Barbara A., Tsherniak, Aviad, Cowley, Glenn S., Root, David E., Asara, John M., Vazquez, Francisca, Widlund, Hans R., Hahn, William C., Kory, Nora, Sabatini, David, Pacold, Michael Edward
Published 2017

Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics

by de Waal, Luc, Lewis, Timothy A, Rees, Matthew G, Tsherniak, Aviad, Wu, Xiaoyun, Choi, Peter S, Gechijian, Lara, Hartigan, Christina, Faloon, Patrick W, Hickey, Mark J, Tolliday, Nicola, Carr, Steven A, Clemons, Paul A, Munoz, Benito, Wagner, Bridget K, Shamji, Alykhan F, Schenone, Monica, Burgin, Alex B, Schreiber, Stuart L, Greulich, Heidi, Meyerson, Matthew, Koehler, Angela Nicole
Published 2017

Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer

by Viswanathan, Srinivas R., Nogueira, Marina F., Buss, Colin G., Krill-Burger, John M., Wawer, Mathias J., Malolepsza, Edyta, Berger, Ashton C., Choi, Peter S., Shih, Juliann, Taylor, Alison M., Tanenbaum, Benjamin, Pedamallu, Chandra Sekhar, Cherniack, Andrew D., Tamayo, Pablo, Strathdee, Craig A., Lage, Kasper, Carr, Steven A., Schenone, Monica, Bhatia, Sangeeta N, Vazquez, Francisca, Tsherniak, Aviad, Hahn, William C., Meyerson, Matthew
Published 2020

Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability

by Paolella, Brenton R, Urbanski, Laura M, Alberta, John A, Bandopadhayay, Pratiti, Nichols, Caitlin A, Agarwalla, Pankaj K, Brown, Meredith S, Lamothe, Rebecca, Yu, Yong, Choi, Peter S, Obeng, Esther A, Heckl, Dirk, Vazquez, Francisca, Buhrlage, Sara J, Stiles, Charles D, Reed, Robin, Gibson, William J, Zack, Travis Ian, Wei, Guo, Wang, Belinda, Tsherniak, Aviad, Weir, Barbara A, Root, David, Cowley, Glenn S, Ebert, Benjamin L, Hahn, William, Beroukhim, Rameen
Published 2017

Genome-scale screens identify factors regulating tumor cell responses to natural killer cells

by Sheffer, Michal, Lowry, Emily, Beelen, Nicky, Borah, Minasri, Amara, Suha Naffar-Abu, Mader, Chris C., Roth, Jennifer A., Tsherniak, Aviad, Freeman, Samuel S., Dashevsky, Olga, Gandolfi, Sara, Bender, Samantha, Bryan, Jordan G., Zhu, Cong, Wang, Li, Tariq, Ifrah, Kamath, Govinda M., Simoes, Ricardo De Matos, Dhimolea, Eugen, Yu, Channing, Hu, Yiguo, Dufva, Olli, Giannakis, Marios, Syrgkanis, Vasilis, Fraenkel, Ernest, Golub, Todd, Romee, Rizwan, Mustjoki, Satu, Culhane, Aedin C., Wieten, Lotte, Mitsiades, Constantine S.
Published 2021

Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer

by Ren, Yin, Meyerson, Matthew L., Drapkin, Ronny, Cheung, Hiu Wing, Cowley, Glenn S., Weir, Barbara A., Boehm, Jesse S., Rusin, Scott, Scott, Justine A., East, Alexandra, Ali, Levi D., Lizotte, Patrick H., Wong, Terence C., Jiang, Guozhi, Hsiao, Jessica, Mermel, Craig H., Getz, Gad, Barretina, Jordi, Gopal, Shuba, Tamayo, Pablo, Gould, Joshua, Tsherniak, Aviad, Stransky, Nicolas, Luo, Biao, Mesirov, Jill P., Garraway, Levi A., Lander, Eric S., Root, David E., Hahn, William C., Bhatia, Sangeeta N
Published 2012

Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma

by Bandopadhayay, Pratiti, Piccioni, Federica, O'Rourke, Ryan, Ho, Patricia, Gonzalez, Elizabeth M., Buchan, Graham, Qian, Kenin, Gionet, Gabrielle, Girard, Emily, Coxon, Margo, Rees, Matthew G., Brenan, Lisa, Dubois, Frank, Shapira, Ofer, Greenwald, Noah F., Pages, Melanie, Balboni Iniguez, Amanda, Paolella, Brenton R., Meng, Alice, Sinai, Claire, Roti, Giovanni, Dharia, Neekesh V., Creech, Amanda, Tanenbaum, Benjamin, Khadka, Prasidda, Tracy, Adam, Tiv, Hong L., Hong, Andrew L., Coy, Shannon, Rashid, Rumana, Lin, Jia-Ren, Cowley, Glenn S., Lam, Fred Chiu-Lai, Goodale, Amy, Lee, Yenarae, Schoolcraft, Kathleen, Vazquez, Francisca, Hahn, William C., Tsherniak, Aviad, Bradner, James E., Yaffe, Michael B, Milde, Till, Pfister, Stefan M., Qi, Jun, Schenone, Monica, Carr, Steven A., Ligon, Keith L., Kieran, Mark W., Santagata, Sandro, Olson, James M., Gokhale, Prafulla C., Jaffe, Jacob D., Root, David E., Stegmaier, Kimberly, Johannessen, Cory M., Beroukhim, Rameen
Published 2020