Comprehensive Mapping of Pluripotent Stem Cell Metabolism Using Dynamic Genome-Scale Network Modeling

by Chandrasekaran, Sriram, Zhang, Jin, Sun, Zhen, Zhang, Li, Ross, Christian A., Huang, Yu-Chung, Asara, John M., Li, Hu, Daley, George Q., Collins, James J.
Published 2018

Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating Cells

by Vander Heiden, Matthew G., Locasale, Jason W., Swanson, Kenneth D., Sharfi, Hadar, Heffron, Gregory J., Amador-Noguez, Daniel, Christofk, Heather R., Wagner, Gerhard, Rabinowitz, Joshua D., Asara, John M., Cantley, Lewis C.
Published 2014

Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

by Vander Heiden, Matthew G., Anastasiou, Dimitrios, Poulogiannis, George, Asara, John M., Boxer, Matthew B., Jiang, Jian-kang, Shen, Min, Gary, Bellinger, Sasaki, Atsuo T., Locasale, Jason W., Auld, Douglas S., Thomas, Craig J., Cantley, Lewis C., Bellinger, Gary
Published 2013

Integrative Genomic Analysis Implicates Gain of PIK3CA at 3q26 and MYC at 8q24 in Chronic Lymphocytic Leukemia

by Brown, Jennifer R., Hanna, Megan, Tesar, Bethany, Werner, Lillian, Pochet, Nathalie, Asara, John M., Wang, Yaoyu E., dal Cin, Paola, Fernandes, Stacey M., Thompson, Christina, MacConaill, Laura, Wu, Catherine J., Van de Peer, Yves, Correll, Mick, Regev, Aviv, Neuberg, Donna S., Freedman, Arnold S.
Published 2014

SIRT1 Activates MAO-A in the Brain to Mediate Anxiety and Exploratory Drive

by Pointer, Kelli, Bell, Eric L., Das, Abhirup, Cohen, Dena E., Asara, John M., Kapur, Karen, Bergmann, Sven, Preisig, Martin, Otowa, Takeshi, Kendler, Kenneth S, Chen, Xiangning, Hettema, John M, van den Oord, Edwin J, Rubio, Justin P., Libert, Sergiy V., Guarente, Leonard Pershing
Published 2014

Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis

by Cox, Andrew G., Tsomides, Allison, Kim, Andrew J., Saunders, Diane, Hwang, Katie L., Evason, Kimberley J., Heidel, Jerry, Brown, Kristin K., Yuan, Min, Lien, Evan C., Lee, Byung Cheon, Nissim, Sahar, Dickinson, Bryan, Chhangawala, Sagar, Asara, John M., Houvras, Yariv, Gladyshev, Vadim N., Goessling, Wolfram, Chang, Christopher J. 1974-
Published 2017

PIK3CA mutant tumors depend on oxoglutarate dehydrogenase

by Ilic, Nina, Birsoy, Kıvanç, Aguirre, Andrew J., Singh, Shambhavi, Moody, Susan E., DeAngelo, Joseph D., Spardy, Nicole A., Freinkman, Elizaveta, Weir, Barbara A., Tsherniak, Aviad, Cowley, Glenn S., Root, David E., Asara, John M., Vazquez, Francisca, Widlund, Hans R., Hahn, William C., Kory, Nora, Sabatini, David, Pacold, Michael Edward
Published 2017

Metabolic Regulation of Protein N-Alpha-Acetylation by Bcl-xL Promotes Cell Survival

by Yi, Caroline H, Pan, Heling, Seebacher, Jan, Jang, Il-Ho, Hyberts, Sven G, Heffron, Gregory J., Vander Heiden, Matthew G, Yang, Renliang, Li, Fupeng, Locasale, Jason W., Sharfi, Hadar, Zhai, Bo, Rodriguez-Mias, Ricard, Luithardt, Harry, Cantley, Lewis C., Daley, George Q., Asara, John M., Gygi, Steven P., Wagner, Gerhard, Liu, Chuan-Fa, Yuan, Junying
Published 2014

KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer

by Krall, Elsa B, Munoz, Diana M, Ilic, Nina, Niederst, Matthew J, Yu, Kristine, Ruddy, David A, Redig, Amanda J, Gainor, Justin F, Williams, Juliet A, Asara, John M, Janne, Pasi A, Shaw, Alice T, McDonald III, Robert E, Engelman, Jeffrey A, Stegmeier, Frank, Schlabach, Michael R, Wang, Belinda, Raghavan, Srivatsan, Aguirre, Andrew J., Kim, Jong Wook, Doench, John Gerard, Hahn, William
Published 2017

Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth

by Cox, Andrew G, Tsomides, Allison, Yimlamai, Dean, Hwang, Katie L, Miesfeld, Joel, Galli, Giorgio G, Fowl, Brendan H, Fort, Michael, Ma, Kimberly Y, Sullivan, Mark R, Hosios, Aaron M, Snay, Erin, Yuan, Min, Brown, Kristin K, Lien, Evan C, Chhangawala, Sagar, Steinhauser, Matthew L, Asara, John M, Houvras, Yariv, Link, Brian, Vander Heiden, Matthew G, Camargo, Fernando D, Goessling, Wolfram
Published 2020

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

by Locasale, Jason W., Grassian, Alexandra R., Melman, Tamar, Lyssiotis, Costas A., Mattaini, Katherine Ruth, Bass, Adam J., Heffron, Gregory J., Metallo, Christian M., Muranen, Taru, Sharfi, Hadar, Sasaki, Atsuo T., Anastasiou, Dimitrios, Mullarky, Edouard, Vokes, Natalie I., Sasaki, Mika, Beroukhim, Rameen, Stephanopoulos, Gregory, Ligon, Azra H., Meyerson, Matthew L., Richardson, Andrea L., Chin, Lynda, Wagner, Gerhard, Asara, John M., Brugge, Joan S., Cantley, Lewis C., Vander Heiden, Matthew G.
Published 2013

Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma

by McBrayer, Samuel K., Mayers, Jared R., DiNatale, Gabriel J., Shi, Diana D., Khanal, Januka, Chakraborty, Abhishek A., Sarosiek, Kristopher A., Briggs, Kimberly J., Robbins, Alissa K., Sewastianik, Tomasz, Shareef, Sarah J., Olenchock, Benjamin A., Parker, Seth J., Tateishi, Kensuke, Spinelli, Jessica B., Islam, Mirazul, Haigis, Marcia C., Looper, Ryan E., Ligon, Keith L., Bernstein, Bradley E., Carrasco, Ruben D., Cahill, Daniel P., Asara, John M., Metallo, Christian M., Yennawar, Neela H., Vander Heiden, Matthew G., Kaelin, William G.
Published 2020

Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma

by Tan, Justin L., Fogley, Rachel D., Flynn, Ryan A., Ablain, Julien, Yang, Song, Do, Brian T., Laga, Alvaro C., Fujinaga, Koh, Santoriello, Cristina, Greer, Celeste B., Kim, Yoon Jung, Clohessy, John G., Bothmer, Anne, Pandell, Nicole, Avagyan, Serine, Brogie, John E., van Rooijen, Ellen, Hagedorn, Elliott J., Shyh-Chang, Ng, White, Richard M., Price, David H., Pandolfi, Pier Paolo, Peterlin, B. Matija, Zhou, Yi, Kim, Tae Hoon, Asara, John M., Chang, Howard Y., Zon, Leonard I., Saint-André, Violaine, Fan, Zi Peng, Young, Richard A.
Published 2018