HSP90 empowers evolution of resistance to hormonal therapy in human breast cancer models

by Whitesell, Luke, Santagata, Sandro, Mendillo, Marc L., Lin, Nancy U., Proia, David A., Lindquist, Susan
Published 2015

Chaperones as thermodynamic sensors of drug-target interactions reveal kinase inhibitor specificities in living cells

by Taipale, Mikko, Krykbaeva, Irina, Whitesell, Luke, Santagata, Sandro, Zhang, Jianming, Liu, Qingsong, Gray, Nathanael S., Lindquist, Susan
Published 2014

Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis

by Dai, Chengkai, Santagata, Sandro, Tang, Zijian, Shi, Jiayuan, Cao, Junxia, Kwon, Hyoungtae, Bronson, Roderick T., Whitesell, Luke, Lindquist, Susan
Published 2014

Rapid Selection of Cyclic Peptides that Reduce Alpha-Synuclein Toxicity in Yeast and Animal Models

by Lindquist, Susan, Caldwell, Guy A., Caldwell, Kim A., Naumann, Todd A., Santagata, Sandro, McCaffery, J. Michael, Hamamichi, Shusei, Kritzer, Joshua A.
Published 2010

HSF1 Drives a Transcriptional Program Distinct from Heat Shock to Support Highly Malignant Human Cancers

by Mendillo, Marc L., Santagata, Sandro, Bell, George W., Hu, Rong, Tamimi, Rulla M, Fraenkel, Ernest, Ince, Tan A., Whitesell, Luke, Lindquist, Susan, Koeva, Martina I
Published 2014

Suppression of 19S proteasome subunits marks emergence of an altered cell state in diverse cancers

by Tsvetkov, Peter, Brune, Zarina, Thiru, Prathapan, Ghandi, Mahmoud, Santagata, Sandro, Whitesell, Luke, Sokol, Ethan Samuel, Jin, Dexter X., Gupta, Piyush, Lindquist, Susan, Garraway, Levi A.
Published 2017

High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer

by Santagata, Sandro, Mendillo, Marc L., Whitesell, Luke, Lindquist, Susan, Hu, Rong, Lin, Nancy U., Collins, Laura C., Hankinson, Susan E., Schnitt, Stuart J., Tamimi, Rulla M., Ince, Tan A.
Published 2012

Rebalancing Protein Homeostasis Enhances Tumor Antigen Presentation

by Jaeger, Alex M., Stopfer, Lauren Elizabeth, Lee, Sunmin, Gaglia, Giorgio, Sandel, Demi, Santagata, Sandro, Lin, Nancy U., Trepel, Jane B., White, Forest M., Jacks, Tyler E, Lindquist, Susan, Whitesell, Luke
Published 2020

Using the Heat-Shock Response To Discover Anticancer Compounds that Target Protein Homeostasis

by Santagata, Sandro, Xu, Ya-ming, Wijeratne, E. M. Kithsiri, Kontnik, Renee, Rooney, Christine, Perley, Casey C., Kwon, Hyoungtae, Clardy, Jon, Kesari, Santosh, Whitesell, Luke, Lindquist, Susan, Gunatilaka, A. A. Leslie
Published 2013

The Reprogramming of Tumor Stroma by HSF1 Is a Potent Enabler of Malignancy

by Scherz-Shouval, Ruth, Santagata, Sandro, Mendillo, Marc L, Sholl, Lynette M, Ben-Aharon, Irit, Beck, Andrew H, Dias-Santagata, Dora, Stemmer, Salomon M, Whitesell, Luke, Koeva, Martina I, Lindquist, Susan
Published 2016

Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome

by Tsvetkov, Peter, Zhao, Jinghui, Cikes, Domagoj, Varadarajan, Malini, Santagata, Sandro, Lindquist, Susan, Mendillo, Marc L., Carette, Jan E., Merrill, Parker H., van Diemen, Ferdy R., Penninger, Josef M., Goldberg, Alfred L., Brummelkamp, Thijn R.
Published 2015

Derivation of Pre-X Inactivation Human Embryonic Stem Cells under Physiological Oxygen Concentrations

by Lengner, Christopher J., Gimelbrant, Alexander A., Erwin, Jennifer A., Cheng, Albert W., Guenther, Matthew G., Welstead, G. Grant, Alagappan, Raaji, Frampton, Garrett M., Xu, Ping, Muffat, Julien, Santagata, Sandro, Powers, Doug, Barrett, C. Brent, Young, Richard A., Lee, Jeannie T., Jaenisch, Rudolf, Mitalipova, Maisam
Published 2015

Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma

by Bandopadhayay, Pratiti, Piccioni, Federica, O'Rourke, Ryan, Ho, Patricia, Gonzalez, Elizabeth M., Buchan, Graham, Qian, Kenin, Gionet, Gabrielle, Girard, Emily, Coxon, Margo, Rees, Matthew G., Brenan, Lisa, Dubois, Frank, Shapira, Ofer, Greenwald, Noah F., Pages, Melanie, Balboni Iniguez, Amanda, Paolella, Brenton R., Meng, Alice, Sinai, Claire, Roti, Giovanni, Dharia, Neekesh V., Creech, Amanda, Tanenbaum, Benjamin, Khadka, Prasidda, Tracy, Adam, Tiv, Hong L., Hong, Andrew L., Coy, Shannon, Rashid, Rumana, Lin, Jia-Ren, Cowley, Glenn S., Lam, Fred Chiu-Lai, Goodale, Amy, Lee, Yenarae, Schoolcraft, Kathleen, Vazquez, Francisca, Hahn, William C., Tsherniak, Aviad, Bradner, James E., Yaffe, Michael B, Milde, Till, Pfister, Stefan M., Qi, Jun, Schenone, Monica, Carr, Steven A., Ligon, Keith L., Kieran, Mark W., Santagata, Sandro, Olson, James M., Gokhale, Prafulla C., Jaffe, Jacob D., Root, David E., Stegmaier, Kimberly, Johannessen, Cory M., Beroukhim, Rameen
Published 2020