Fitness Trade-offs Restrict the Evolution of Resistance to Amphotericin B

by Vincent, Benjamin Matteson, Lancaster, Alex K., Scherz-Shouval, Ruth, Whitesell, Luke, Lindquist, Susan
Published 2013

HSP90 empowers evolution of resistance to hormonal therapy in human breast cancer models

by Whitesell, Luke, Santagata, Sandro, Mendillo, Marc L., Lin, Nancy U., Proia, David A., Lindquist, Susan
Published 2015

Inhibiting GPI Anchor Biosynthesis in Fungi Stresses the Endoplasmic Reticulum and Enhances Immunogenicity

by McLellan, Catherine A., Whitesell, Luke, King, Oliver D., Lancaster, Alex K., Mazitschek, Ralph, Lindquist, Susan
Published 2014

Chaperones as thermodynamic sensors of drug-target interactions reveal kinase inhibitor specificities in living cells

by Taipale, Mikko, Krykbaeva, Irina, Whitesell, Luke, Santagata, Sandro, Zhang, Jianming, Liu, Qingsong, Gray, Nathanael S., Lindquist, Susan
Published 2014

Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis

by Dai, Chengkai, Santagata, Sandro, Tang, Zijian, Shi, Jiayuan, Cao, Junxia, Kwon, Hyoungtae, Bronson, Roderick T., Whitesell, Luke, Lindquist, Susan
Published 2014

Nontoxic antimicrobials that evade drug resistance

by Davis, Stephen A, Endo, Matthew M, Whitesell, Luke, Marchillo, Karen, Andes, David R, Burke, Martin D, Vincent, Benjamin Matteson, Lindquist, Susan
Published 2016

A Fungal-Selective Cytochrome bc₁ Inhibitor Impairs Virulence and Prevents the Evolution of Drug Resistance

by Srinivas, Raja, Lancaster, Alex K, Scherz-Shouval, Ruth, Whitesell, Luke, Vincent, Benjamin Matteson, Langlois, Jean-Baptiste, Tidor, Bruce, Buchwald, Stephen Leffler, Lindquist, Susan
Published 2017

Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles

by Youngsaye, Willmen, Dockendorff, Chris, Hartland, Cathy L., Bittker, Joshua A., Dandapani, Sivaraman, Palmer, Michelle, Whitesell, Luke, Lindquist, Susan, Schreiber, Stuart L., Munoz, Benito
Published 2014

HSF1 Drives a Transcriptional Program Distinct from Heat Shock to Support Highly Malignant Human Cancers

by Mendillo, Marc L., Santagata, Sandro, Bell, George W., Hu, Rong, Tamimi, Rulla M, Fraenkel, Ernest, Ince, Tan A., Whitesell, Luke, Lindquist, Susan, Koeva, Martina I
Published 2014

Suppression of 19S proteasome subunits marks emergence of an altered cell state in diverse cancers

by Tsvetkov, Peter, Brune, Zarina, Thiru, Prathapan, Ghandi, Mahmoud, Santagata, Sandro, Whitesell, Luke, Sokol, Ethan Samuel, Jin, Dexter X., Gupta, Piyush, Lindquist, Susan, Garraway, Levi A.
Published 2017

High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer

by Santagata, Sandro, Mendillo, Marc L., Whitesell, Luke, Lindquist, Susan, Hu, Rong, Lin, Nancy U., Collins, Laura C., Hankinson, Susan E., Schnitt, Stuart J., Tamimi, Rulla M., Ince, Tan A.
Published 2012

Rebalancing Protein Homeostasis Enhances Tumor Antigen Presentation

by Jaeger, Alex M., Stopfer, Lauren Elizabeth, Lee, Sunmin, Gaglia, Giorgio, Sandel, Demi, Santagata, Sandro, Lin, Nancy U., Trepel, Jane B., White, Forest M., Jacks, Tyler E, Lindquist, Susan, Whitesell, Luke
Published 2020

Using the Heat-Shock Response To Discover Anticancer Compounds that Target Protein Homeostasis

by Santagata, Sandro, Xu, Ya-ming, Wijeratne, E. M. Kithsiri, Kontnik, Renee, Rooney, Christine, Perley, Casey C., Kwon, Hyoungtae, Clardy, Jon, Kesari, Santosh, Whitesell, Luke, Lindquist, Susan, Gunatilaka, A. A. Leslie
Published 2013

The Reprogramming of Tumor Stroma by HSF1 Is a Potent Enabler of Malignancy

by Scherz-Shouval, Ruth, Santagata, Sandro, Mendillo, Marc L, Sholl, Lynette M, Ben-Aharon, Irit, Beck, Andrew H, Dias-Santagata, Dora, Stemmer, Salomon M, Whitesell, Luke, Koeva, Martina I, Lindquist, Susan
Published 2016

Piperazinyl quinolines as chemosensitizers to increase fluconazole susceptibility of Candida albicans clinical isolates

by Youngsaye, Willmen, Vincent, Benjamin, Hartland, Cathy L., Morgan, Barbara J., Buhrlage, Sara J., Johnston, Stephen, Bittker, Joshua A., MacPherson, Lawrence, Dandapani, Sivaraman, Palmer, Michelle, Whitesell, Luke, Lindquist, Susan, Schreiber, Stuart L., Munoz, Benito
Published 2015

Calcineurin determines toxic versus beneficial responses to  α-synuclein

by Caraveo, Gabriela, Baru, Valeriya, Lindquist, Susan, Auluck, Pavan K., Whitesell, Luke, Chung, Chee Yeun, Mosharov, Eugene V., Yan, Xiohui, Ben-Johny, Manu, Soste, Martin, Picotti, Paola, Kim, Hanna, Caldwell, Kim A., Caldwell, Guy A., Sulzer, David, Yue, David T.
Published 2015