One-Step Generation of Mice Carrying Reporter and Conditional Alleles by CRISPR/Cas-Mediated Genome Engineering

by Yang, Hui, Wang, Haoyi, Cheng, Albert W, Shi, Linyu, Shivalila, Chikdu Shakti, Jaenisch, Rudolf
Published 2017

SOX2 Co-Occupies Distal Enhancer Elements with Distinct POU Factors in ESCs and NPCs to Specify Cell State

by Lodato, Michael Anthony, Ng, Christopher W., Wamstad, Joseph Alan, Cheng, Albert W., Thai, Kevin Kinh, Fraenkel, Ernest, Jaenisch, Rudolf, Boyer, Laurie
Published 2013

Tet1 Is Critical for Neuronal Activity-Regulated Gene Expression and Memory Extinction

by Rudenko, Andrii, Dawlaty, Meelad M, Seo, Jinsoo, Cheng, Albert W, Meng, Jia, Le, Thuc, Faull, Kym F, Jaenisch, Rudolf, Tsai, Li-Huei
Published 2016

Human embryonic stem cells with biological and epigenetic to those of mouse ESCs

by Jaenisch, Rudolf, Hanna, Jacob, Cheng, Albert W., Saha, Krishanu, Kim, Jongpil, Lengner, Christopher J., Soldner, Frank, Cassady, John P., Muffat, Julien, Carey, Bryce W.
Published 2011

Loss of Tet Enzymes Compromises Proper Differentiation of Embryonic Stem Cells

by Dawlaty, Meelad M, Breiling, Achim, Le, Thuc, Barrasa, M. Inmaculada, Raddatz, Günter, Gao, Qing, Powell, Benjamin E, Cheng, Albert W, Faull, Kym F, Lyko, Frank, Jaenisch, Rudolf
Published 2016

Tet1 Is Dispensable for Maintaining Pluripotency and Its Loss Is Compatible with Embryonic and Postnatal Development

by Dawlaty, Meelad M., Ganz, Kibibi, Powell, Benjamin E, Hu, Yueh-Chiang, Markoulaki, Styliani, Cheng, Albert W., Gao, Qing, Kim, Jongpil, Choi, Sang-Woon, Jaenisch, Rudolf, Page, David C
Published 2014

Functional Integration of Dopaminergic Neurons Directly Converted from Mouse Fibroblasts

by Kim, Jongpil, Su, Susan C, Wang, Haoyi, Cheng, Albert W., Cassady, John P., Lodato, Michael Anthony, Lengner, Christopher J., Chung, Chee Yeun, Dawlaty, Meelad M., Tsai, Li-Huei, Jaenisch, Rudolf
Published 2014

Musashi proteins are post-transcriptional regulators of the epithelial-luminal cell state

by Katz, Yarden, Li, Feifei, Lambert, Nicole J., Tam, Wai-Leong, Airoldi, Edoardo M., Lengner, Christopher J., Yu, Zhengquan, Jaenisch, Rudolf, Sokol, Ethan Samuel, Cheng, Albert W., Gupta, Piyush, Burge, Christopher B
Published 2014

Combined Deficiency of Tet1 and Tet2 Causes Epigenetic Abnormalities but Is Compatible with Postnatal Development

by Dawlaty, Meelad M, Breiling, Achim, Le, Thuc, Raddatz, Günter, Barrasa, M. Inmaculada, Cheng, Albert W, Gao, Qing, Powell, Benjamin E, Li, Zhe, Xu, Mingjiang, Faull, Kym F, Lyko, Frank, Jaenisch, Rudolf
Published 2017

Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells

by Wu, Xuebing, Cheng, Albert W., Chen, Sidi, Jaenisch, Rudolf, Zhang, Feng, Chiu, Anthony Chun-yin, Sharp, Phillip A., Scott, David Arthur, Hsu, Patrick, Trevino, Alexandro E., Kriz, Andrea J., Dadon, Daniel Benjamin, Konermann, Silvana M
Published 2015

Histone H3K27ac separates active from poised enhancers and predicts developmental state

by Creyghton, Menno P., Cheng, Albert W., Welstead, G. Grant, Kooistra, Tristan G., Carey, Bryce W., Steine, Eveline J., Hanna, Jacob, Lodato, Michael Anthony, Frampton, Garrett M., Sharp, Phillip A., Boyer, Laurie, Young, Richard A., Jaenisch, Rudolf
Published 2014

Derivation of Pre-X Inactivation Human Embryonic Stem Cells under Physiological Oxygen Concentrations

by Lengner, Christopher J., Gimelbrant, Alexander A., Erwin, Jennifer A., Cheng, Albert W., Guenther, Matthew G., Welstead, G. Grant, Alagappan, Raaji, Frampton, Garrett M., Xu, Ping, Muffat, Julien, Santagata, Sandro, Powers, Doug, Barrett, C. Brent, Young, Richard A., Lee, Jeannie T., Jaenisch, Rudolf, Mitalipova, Maisam
Published 2015

Global Transcriptional and Translational Repression in Human-Embryonic-Stem-Cell-Derived Rett Syndrome Neurons

by Li, Yun, Wang, Haoyi, Muffat, Julien, Cheng, Albert W, Orlando, David A., Feldman, Danielle A, Bateup, Helen S, Gao, Qing, Hockemeyer, Dirk, Mitalipova, Maisam, Lewis, Caroline A, Sur, Mriganka, Young, Richard A, Jaenisch, Rudolf, Loven, Jakob, Vander Heiden, Matthew G., Feldman, Danielle A., Young, Richard A., Lewis, Caroline, Kwok, Show Ming
Published 2016

Direct Reprogramming of Fibroblasts into Embryonic Sertoli-like Cells by Defined Factors

by Buganim, Yosef, Itskovich, Elena, Hu, Yueh-Chiang, Ganz, Kibibi, Sarkar, Sovan, Fu, Dongdong, Welstead, G. Grant, Jaenisch, Rudolf, Cheng, Albert Wu, Page, David C
Published 2014

Generation of Isogenic Pluripotent Stem Cells Differing Exclusively at Two Early Onset Parkinson Point Mutations

by Soldner, Frank, Hockemeyer, Dirk, Gao, Qing, Alagappan, Raaji, Khurana, Vikram, Golbe, Lawrence I, Myers, Richard H., Lindquist, Susan, Guschin, Dmitry, Fong, Lauren K, Vu, B. Joseph, Meng, Xiangdong, Urnov, Fyodor D, Rebar, Edward J, Gregory, Philip D., Zhang, H. Steve, Jaenisch, Rudolf, Laganiere, Josee, Zhang, Lei, Ph. D Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, fl. 2014, Cheng, Albert Wu
Published 2014

X-linked H3K27me3 demethylase Utx is required for embryonic development in a sex-specific manner

by Welstead, G. Grant, Creyghton, Menno P., Bilodeau, Steve, Markoulaki, Styliani, Young, Richard A., Jaenisch, Rudolf, Cheng, Albert Wu
Published 2013

Metastable Pluripotent States in NOD Mouse Derived ES Cells

by Hanna, Jacob, Markoulaki, Styliani, Mitalipova, Maisam, Cassady, John P., Staerk, Judith, Carey, Bryce W., Lengner, Christopher J., Foreman, Ruth K., Love, Jennifer, Gao, Qing, Kim, Jongpil, Jaenisch, Rudolf, Cheng, Albert Wu
Published 2012

Genetic and Chemical Correction of Cholesterol Accumulation and Impaired Autophagy in Hepatic and Neural Cells Derived from Niemann-Pick Type C Patient-Specific iPS Cells

by Maetzel, Dorothea, Sarkar, Sovan, Wang, Haoyi, Abi-Mosleh, Lina, Xu, Ping, Gao, Qing, Mitalipova, Maisam, Jaenisch, Rudolf, Cheng, Albert Wu
Published 2015

Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system

by Wang, Haoyi, Yang, Hui, Shi, Linyu, Katz, Yarden, Theunissen, Thorold W, Rangarajan, Sudharshan, Jaenisch, Rudolf, Shivalila, Chikdu Shakti, Dadon, Daniel Benjamin, Cheng, Albert Wu
Published 2014

Single-Cell Expression Analyses during Cellular Reprogramming Reveal an Early Stochastic and a Late Hierarchic Phase

by Buganim, Yosef, Faddah, Dina A., Itskovich, Elena, Markoulaki, Styliani, Ganz, Kibibi, van Oudenaarden, Alexander, Jaenisch, Rudolf, Klemm, Sandy Lee, van Oudenaarden, Alexander, Cheng, Albert Wu
Published 2014