Exploiting glycan topography for computational design of Env glycoprotein antigenicity

Exploiting glycan topography for computational design of Env glycoprotein antigenicity

Mounting evidence suggests that glycans, rather than merely serving as a "shield", contribute critically to antigenicity of the HIV envelope (Env) glycoprotein, representing critical antigenic determinants for many broadly neutralizing antibodies (bNAbs). While many studies have focused on...

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Main Authors: Zhao, Peng (Author), Draghi, Monia (Author), Arevalo, Claudia (Author), Karsten, Christina B. (Author), Suscovich, Todd J. (Author), Gunn, Bronwyn (Author), Streeck, Hendrik (Author), Brass, Abraham L. (Author), Tiemeyer, Michael (Author), Seaman, Michael (Author), Mascola, John R. (Author), Wells, Lance (Author), Alter, Galit (Author), Yu, Wen-Han (Contributor), Lauffenburger, Douglas A (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2018-09-11T14:02:57Z.
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