Sustained intra-cartilage delivery of low dose dexamethasone using a cationic carrier for treatment of post traumatic osteoarthritis

Sustained intra-cartilage delivery of low dose dexamethasone using a cationic carrier for treatment of post traumatic osteoarthritis

Disease-modifying osteoarthritis drugs (DMOADs) should reach their intra-tissue target sites at optimal doses for clinical efficacy. The dense, negatively charged matrix of cartilage poses a major hindrance to the transport of potential therapeutics. In this work, electrostatic interactions were uti...

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Bibliographic Details
Main Authors: De la Vega, RE (Author), Scheu, M (Author), Brown, LA (Author), Fitzsimons, TJ (Author), Porter, RM (Author), Bajpayee, Ambika Goel (Contributor), Varady, Nathan H. (Contributor), Yannatos, I. A. (Contributor), Krishnan, Yamini (Contributor), Bhattacharya, Paulomi (Contributor), Frank, Eliot Henry (Contributor), Grodzinsky, Alan J (Contributor), Porter, R. M. (Contributor)
Other Authors: Massachusetts Institute of Technology. Center for Biomedical Engineering (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science (Contributor), Massachusetts Institute of Technology. Department of Mechanical Engineering (Contributor)
Format: Article
Language:English
Published: ECM Research Journal, 2018-09-13T15:58:32Z.
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