Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases

Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases

The survival benefit of anti-vascular endothelial growth factor (VEGF) therapy in metastatic colorectal cancer (mCRC) patients is limited to a few months because of acquired resistance. We show that anti-VEGF therapy induced remodeling of the extracellular matrix with subsequent alteration of the ph...

Full description

Bibliographic Details
Main Authors: Rahbari, N. N. (Author), Kedrin, D. (Author), Incio, J. (Author), Liu, H. (Author), Nia, H. T. (Author), Edrich, C. M. (Author), Jung, K. (Author), Daubriac, J. (Author), Chen, I. (Author), Heishi, T. (Author), Martin, J. D. (Author), Huang, Y. (Author), Maimon, N. (Author), Reissfelder, C. (Author), Weitz, J. (Author), Boucher, Y. (Author), Clark, J. W. (Author), Duda, D. G. (Author), Jain, R. K. (Author), Fukumura, D. (Author), Ho, William W. (Contributor), Grodzinsky, Alan J (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Massachusetts Institute of Technology. Department of Mechanical Engineering (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS), 2018-09-13T17:38:01Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items