Antigen recognition-triggered drug delivery mediated by nanocapsule-functionalized cytotoxic T-cells

Antigen recognition-triggered drug delivery mediated by nanocapsule-functionalized cytotoxic T-cells

Cytotoxic T-Lymphocytes (CTLs) kill pathogen-infected or transformed cells following interaction of their T-cell receptors (TCRs) with foreign (e.g. virus-derived) peptides bound to MHC-I molecules on the target cell. TCR binding triggers CTLs to secrete perforin, which forms pores in the target cel...

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Bibliographic Details
Main Authors: Mueller, Stephanie (Author), Vrbanac, Vlad (Author), Genel, Shy (Author), Tager, Andrew M. (Author), Allen, Todd M. (Author), Jones, Richard Bradley (Contributor), Kumari, Sudha (Contributor), Walker, Bruce (Contributor), Irvine, Darrell J (Contributor)
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Materials Science and Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier BV, 2018-09-17T12:42:03Z.
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