Oncometabolites D- and L-2-hydroxyglutarate Inhibit the AlkB Family DNA Repair Enzymes under Physiological Conditions

Oncometabolites D- and L-2-hydroxyglutarate Inhibit the AlkB Family DNA Repair Enzymes under Physiological Conditions

Cancer-associated mutations often lead to perturbed cellular energy metabolism and accumulation of potentially harmful oncometabolites. One example is the chiral molecule 2-hydroxyglutarate (2HG); its two stereoisomers (d- and l-2HG) have been found at abnormally high concentrations in tumors featur...

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Bibliographic Details
Main Authors: Chen, Fangyi (Author), Bian, Ke (Author), Tang, Qi (Author), Humulock, Zachary T. (Author), Li, Deyu (Contributor), Fedeles, Bogdan I (Contributor), Singh, Vipender (Contributor), Essigmann, John M. (Author)
Other Authors: Massachusetts Institute of Technology. Center for Environmental Health Sciences (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Essigmann, John M (Contributor)
Format: Article
Language:English
Published: American Chemical Society (ACS), 2018-09-17T16:16:25Z.
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