Aneuploid Cell Survival Relies upon Sphingolipid Homeostasis

Aneuploid Cell Survival Relies upon Sphingolipid Homeostasis

Aneuploidy, a hallmark of cancer cells, poses an appealing opportunity for cancer treatment and prevention strategies. Using a cell-based screen to identify small molecules that could selectively kill aneuploid cells, we identified the compound N-[2hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-deca...

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Main Authors: Tang, Yun-Chi (Author), Yuwen, Hui (Author), Wang, Kaiying (Author), Bruno, Peter M. (Author), Bullock, Kevin (Author), Deik, Amy (Author), Zhong, Na (Author), Huang, Tao (Author), Wang, Lan (Author), Clish, Clary B. (Author), Hemann, Michael T. (Author), Santaguida, Stefano (Contributor), Trakala, Marianna (Contributor), Pfau, Sarah Jeanne (Contributor), Amon, Angelika B (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: American Association for Cancer Research (AACR), 2018-10-31T19:27:03Z.
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