Aneuploid Cell Survival Relies upon Sphingolipid Homeostasis
Aneuploidy, a hallmark of cancer cells, poses an appealing opportunity for cancer treatment and prevention strategies. Using a cell-based screen to identify small molecules that could selectively kill aneuploid cells, we identified the compound N-[2hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-deca...
Main Authors: | Tang, Yun-Chi (Author), Yuwen, Hui (Author), Wang, Kaiying (Author), Bruno, Peter M. (Author), Bullock, Kevin (Author), Deik, Amy (Author), Zhong, Na (Author), Huang, Tao (Author), Wang, Lan (Author), Clish, Clary B. (Author), Hemann, Michael T. (Author), Santaguida, Stefano (Contributor), Trakala, Marianna (Contributor), Pfau, Sarah Jeanne (Contributor), Amon, Angelika B (Contributor) |
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Other Authors: | Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor) |
Format: | Article |
Language: | English |
Published: |
American Association for Cancer Research (AACR),
2018-10-31T19:27:03Z.
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Subjects: | |
Online Access: | Get fulltext |
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