mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient

mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient

The mTORC1 kinase is a master growth regulator that senses many environmental cues, including amino acids. Activation of mTORC1 by arginine requires SLC38A9, a poorly understood lysosomal membrane protein with homology to amino acid transporters. Here, we validate that SLC38A9 is an arginine sensor...

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Bibliographic Details
Main Authors: Freinkman, Elizaveta (Author), Wyant, Gregory Andrew (Contributor), Abu-Remaileh, Monther (Contributor), Wolfson, Rachel Laura (Contributor), Chen, Walter W. (Contributor), Danai, Laura V (Contributor), Vander Heiden, Matthew G. (Contributor), Sabatini, David (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier, 2018-11-07T16:47:17Z.
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