mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient
The mTORC1 kinase is a master growth regulator that senses many environmental cues, including amino acids. Activation of mTORC1 by arginine requires SLC38A9, a poorly understood lysosomal membrane protein with homology to amino acid transporters. Here, we validate that SLC38A9 is an arginine sensor...
Main Authors: | Freinkman, Elizaveta (Author), Wyant, Gregory Andrew (Contributor), Abu-Remaileh, Monther (Contributor), Wolfson, Rachel Laura (Contributor), Chen, Walter W. (Contributor), Danai, Laura V (Contributor), Vander Heiden, Matthew G. (Contributor), Sabatini, David (Contributor) |
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Other Authors: | Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor) |
Format: | Article |
Language: | English |
Published: |
Elsevier,
2018-11-07T16:47:17Z.
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Subjects: | |
Online Access: | Get fulltext |
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