MK2 contributes to tumor progression by promoting M2 macrophage polarization and tumor angiogenesis

MK2 contributes to tumor progression by promoting M2 macrophage polarization and tumor angiogenesis

Chronic inflammation is a major risk factor for colorectal cancer. The p38/MAPKAP Kinase 2 (MK2) kinase axis controls the synthesis of proinflammatory cytokines that mediate both chronic inflammation and tumor progression. Blockade of this pathway has been previously reported to suppress inflammatio...

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Bibliographic Details
Main Authors: Haigis, Kevin M. (Author), Suarez Lopez, Lucia (Contributor), Kong, Yi Wen (Contributor), Sriram, Ganapathy (Contributor), Morandell, Sandra M. (Contributor), Merrick, Karl Andrew (Contributor), Hernandez, Yuliana I (Contributor), Yaffe, Michael B (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Proceedings of the National Academy of Sciences, 2018-12-04T19:02:22Z.
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