Synthetic RNA-Based Immunomodulatory Gene Circuits for Cancer Immunotherapy

Synthetic RNA-Based Immunomodulatory Gene Circuits for Cancer Immunotherapy

Despite its success in several clinical trials, cancer immunotherapy remains limited by the rarity of targetable tumor-specific antigens, tumor-mediated immune suppression, and toxicity triggered by systemic delivery of potent immunomodulators. Here, we present a proof-of-concept immunomodulatory ge...

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Main Authors: Stupp, Doron (Author), Tabach, Yuval (Author), Suzuki, Hiroshi (Contributor), Lu, Timothy K (Contributor), Nissim, Lior (Contributor), Wu, Ming-Ru (Contributor), Pery, Erez (Contributor), Nissim, Adina (Contributor), Wehrspaun, Claudia Constanze (Contributor), Sharp, Phillip A. (Author)
Other Authors: Massachusetts Institute of Technology. Center for Microbiome Informatics and Therapeutics (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Research Laboratory of Electronics (Contributor), Massachusetts Institute of Technology. Synthetic Biology Center (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Sharp, Phillip A (Contributor)
Format: Article
Language:English
Published: Elsevier BV, 2018-12-11T21:02:36Z.
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