Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer

Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer

The diverse malignant, stromal, and immune cells in tumors affect growth, metastasis, and response to therapy. We profiled transcriptomes of ∼6,000 single cells from 18 head and neck squamous cell carcinoma (HNSCC) patients, including five matched pairs of primary tumors and lymph node metastases. S...

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Main Authors: Puram, Sidharth V. (Author), Tirosh, Itay (Author), Parikh, Anuraag S. (Author), Patel, Anoop P. (Author), Yizhak, Keren (Author), Gillespie, Shawn (Author), Rodman, Christopher (Author), Luo, Christina L. (Author), Mroz, Edmund A. (Author), Emerick, Kevin S. (Author), Deschler, Daniel G. (Author), Varvares, Mark A. (Author), Mylvaganam, Ravi (Author), Rozenblatt-Rosen, Orit (Author), Rocco, James W. (Author), Faquin, William C. (Author), Lin, Derrick T. (Author), Regev, Aviv (Contributor), Bernstein, Bradley E. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier, 2018-12-21T20:45:42Z.
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