Enhancing T cell therapy through TCR-signaling-responsive nanoparticle drug delivery

Enhancing T cell therapy through TCR-signaling-responsive nanoparticle drug delivery

Adoptive cell therapy (ACT) with antigen-specific T cells has shown remarkable clinical success; however, approaches to safely and effectively augment T cell function, especially in solid tumors, remain of great interest. Here we describe a strategy to 'backpack' large quantities of suppor...

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Bibliographic Details
Main Authors: Tang, Li (Contributor), Zheng, Yiran (Contributor), Melo, Mariane Bandeira (Contributor), Mabardi, Llian (Contributor), Castaño, Ana P (Author), Xie, Yu-Qing (Author), Li, Na (Contributor), Kudchodkar, Sagar B (Author), Wong, Hing C (Author), Jeng, Emily K (Author), Maus, Marcela V (Author), Irvine, Darrell J (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Materials Science and Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2019-01-18T15:15:02Z.
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