SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway

SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway

mTOR complex 1 (mTORC1) regulates cell growth and metabolism in response to multiple environmental cues. Nutrients signal via the Rag guanosine triphosphatases (GTPases) to promote the localization of mTORC1 to the lysosomal surface, its site of activation. We identified SAMTOR, a previously unchara...

Full description

Bibliographic Details
Main Authors: Harper, J. Wade (Author), Gygi, Steven P. (Author), Gu, Xin (Contributor), Orozco Segrera, Jose (Contributor), Saxton, Robert Andrew (Contributor), Condon, Kendall Janine (Contributor), Liu, Grace Yun (Contributor), Krawczyk, Patrycja A. (Contributor), Scaria, Sonia M. (Contributor), Sabatini, David (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS), 2019-01-24T21:30:24Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items