Antibiotic-Induced Changes to the Host Metabolic Environment Inhibit Drug Efficacy and Alter Immune Function

Antibiotic-Induced Changes to the Host Metabolic Environment Inhibit Drug Efficacy and Alter Immune Function

Bactericidal antibiotics alter microbial metabolism as part of their lethality and can damage mitochondria in mammalian cells. In addition, antibiotic susceptibility is sensitive to extracellular metabolites, but it remains unknown whether metabolites present at an infection site can affect either t...

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Bibliographic Details
Main Authors: McCloskey, Douglas (Author), Palsson, Bernhard O. (Author), Yang, Jason Hung-Ying (Contributor), Saluja, Prerna Bhargava (Contributor), Mao, Ning (Contributor), Collins, James J. (Contributor)
Other Authors: Institute for Medical Engineering and Science (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor)
Format: Article
Language:English
Published: Elsevier BV, 2019-01-24T21:55:37Z.
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