Targeting small molecule drugs to T cells with antibody-directed cell-penetrating gold nanoparticles

Targeting small molecule drugs to T cells with antibody-directed cell-penetrating gold nanoparticles

We sought to develop a nanoparticle vehicle that could efficiently deliver small molecule drugs to target lymphocyte populations. The synthesized amphiphilic organic ligand-protected gold nanoparticles (amph-NPs) were capable of sequestering large payloads of small molecule drugs within hydrophobic...

Full description

Bibliographic Details
Main Authors: Bekdemir, Ahmet (Author), Watson, Nicki (Author), Ingram, Jessica (Author), Stellacci, Francesco R. (Author), Yang, Yu-Sang Sabrina (Contributor), Moynihan, Kelly Dare (Contributor), Dichwalkar, Tanmay M (Contributor), Noh, Michelle M. (Contributor), Melo, Mariane Bandeira (Contributor), Suh, Heikyung (Contributor), Ploegh, Hidde (Contributor), Irvine, Darrell J (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Materials Science and Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Royal Society of Chemistry, 2019-02-04T15:43:27Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items