Dynamic control of endogenous metabolism with combinatorial logic circuits

Controlling gene expression during a bioprocess enables real-time metabolic control, coordinated cellular responses, and staging order-of-operations. Achieving this with small molecule inducers is impractical at scale and dynamic circuits are difficult to design. Here, we show that the same set of s...

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Bibliographic Details
Main Authors: Moser, Felix (Contributor), Espah Borujeni, Amin (Contributor), Ghodasara, Amar Navin (Contributor), Cameron, Douglas (Contributor), Park, YongJin (Contributor), Voigt, Christopher A. (Contributor)
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2019-03-29T19:41:50Z.
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