Allele-specific epigenome maps reveal sequence-dependent stochastic switching at regulatory loci

Allele-specific epigenome maps reveal sequence-dependent stochastic switching at regulatory loci

To assess the impact of genetic variation in regulatory loci on human health, we constructed a high-resolution map of allelic imbalances in DNA methylation, histone marks, and gene transcription in 71 epigenomes from 36 distinct cell and tissue types from 13 donors. Deep whole-genome bisulfite seque...

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Main Authors: Altshuler, Robert Charles (Author), Onuchic, Vitor (Author), Lurie, Eugene (Author), Carrero, Ivenise (Author), Pawliczek, Piotr (Author), Patel, Ronak Y. (Author), Rozowsky, Joel (Author), Galeev, Timur (Author), Huang, Zhuoyi (Author), Harris, R. Alan (Author), Coarfa, Cristian (Author), Ashmore, Lillian (Author), Bertol, Jessica W. (Author), Fakhouri, Walid D. (Author), Yu, Fuli (Author), Kellis, Manolis (Author), Gerstein, Mark (Author), Milosavljevic, Aleksandar (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS), 2019-06-07T14:55:32Z.
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