Heterogeneous Responses of Hematopoietic Stem Cells to Inflammatory Stimuli Are Altered with Age

Heterogeneous Responses of Hematopoietic Stem Cells to Inflammatory Stimuli Are Altered with Age

Long-term hematopoietic stem cells (LT-HSCs) maintain hematopoietic output throughout an animal's lifespan. However, with age, the balance is disrupted, and LT-HSCs produce a myeloid-biased output, resulting in poor immune responses to infectious challenge and the development of myeloid leukemi...

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Bibliographic Details
Main Authors: Mann, Mati (Author), Mehta, Arnav (Author), de Boer, Carl G. (Author), Kowalczyk, Monika S. (Author), Lee, Kevin (Author), Haldeman, Pearce (Author), Rogel, Noga (Author), Knecht, Abigail R. (Author), Farouq, Daneyal (Author), Regev, Aviv (Author), Baltimore, David (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier, 2019-06-11T20:37:56Z.
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