RAB7A phosphorylation by TBK1 promotes mitophagy via the PINK-PARKIN pathway

RAB7A phosphorylation by TBK1 promotes mitophagy via the PINK-PARKIN pathway

Removal of damaged mitochondria is orchestrated by a pathway involving the PINK1 kinase and the PARKIN ubiquitin ligase. Ubiquitin chains assembled by PARKIN on the mitochondrial outer membrane recruit autophagy cargo receptors in complexes with TBK1 protein kinase. While TBK1 is known to phosphoryl...

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Bibliographic Details
Main Authors: Heo, J.-M (Author), Ordureau, A. (Author), Swarup, S. (Author), Paulo, J. A. (Author), Shen, K. (Author), Sabatini, David (Author), Harper, J. W. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS), 2019-06-18T19:37:26Z.
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