MicroRNA regulation of the MRN complex impacts DNA damage, cellular senescence, and angiogenic signaling

MicroRNA regulation of the MRN complex impacts DNA damage, cellular senescence, and angiogenic signaling

MicroRNAs (miRs) contribute to biological robustness by buffering cellular processes from external perturbations. Here we report an unexpected link between DNA damage response and angiogenic signaling that is buffered by a miR. We demonstrate that genotoxic stress-induced miR-494 inhibits the DNA re...

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Bibliographic Details
Main Authors: Espinosa-Diez, Cristina (Author), Wilson, RaeAnna (Author), Chatterjee, Namita (Author), Hudson, Clayton (Author), Ruhl, Rebecca (Author), Hipfinger, Christina (Author), Helms, Erin (Author), Khan, Omar Fizal (Author), Anderson, Daniel Griffith (Author), Anand, Sudarshan (Author)
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Harvard University- (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Springer Science and Business Media LLC, 2019-08-09T16:03:30Z.
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