Inhaled Nanoformulated mRNA Polyplexes for Protein Production in Lung Epithelium

Inhaled Nanoformulated mRNA Polyplexes for Protein Production in Lung Epithelium

Noninvasive aerosol inhalation is an established method of drug delivery to the lung, and remains a desirable route for nucleic-acid-based therapeutics. In vitro transcribed (IVT) mRNA has broad therapeutic applicability as it permits temporal and dose-dependent control of encoded protein expression...

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Main Authors: Patel, Asha Kumari (Author), Kaczmarek, James Cliff (Author), Bose, Suman (Author), Kauffman, Kevin John (Author), Mir, Faryal (Author), Heartlein, Michael W. (Author), DeRosa, Frank (Author), Langer, Robert S (Author), Anderson, Daniel Griffith (Author)
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Harvard University- (Contributor), Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Wiley, 2019-08-12T15:28:25Z.
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