Inhaled Nanoformulated mRNA Polyplexes for Protein Production in Lung Epithelium
Noninvasive aerosol inhalation is an established method of drug delivery to the lung, and remains a desirable route for nucleic-acid-based therapeutics. In vitro transcribed (IVT) mRNA has broad therapeutic applicability as it permits temporal and dose-dependent control of encoded protein expression...
Main Authors: | Patel, Asha Kumari (Author), Kaczmarek, James Cliff (Author), Bose, Suman (Author), Kauffman, Kevin John (Author), Mir, Faryal (Author), Heartlein, Michael W. (Author), DeRosa, Frank (Author), Langer, Robert S (Author), Anderson, Daniel Griffith (Author) |
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Other Authors: | Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Harvard University- (Contributor), Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor) |
Format: | Article |
Language: | English |
Published: |
Wiley,
2019-08-12T15:28:25Z.
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Subjects: | |
Online Access: | Get fulltext |
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