Genome-Wide CRISPR Screen Identifies Regulators of Mitogen-Activated Protein Kinase as Suppressors of Liver Tumors in Mice

Genome-Wide CRISPR Screen Identifies Regulators of Mitogen-Activated Protein Kinase as Suppressors of Liver Tumors in Mice

Background & Aims It has been a challenge to identify liver tumor suppressors or oncogenes due to the genetic heterogeneity of these tumors. We performed a genome-wide screen to identify suppressors of liver tumor formation in mice, using CRISPR-mediated genome editing. Methods We performed a ge...

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Main Authors: Song, Chun-Qing (Author), Li, Yingxiang (Author), Mou, Haiwei (Author), Moore, Jill (Author), Park, Angela (Author), Pomyen, Yotsawat (Author), Hough, Soren (Author), Kennedy, Zachary (Author), Fischer, Andrew (Author), Yin, Hao (Author), Anderson, Daniel Griffith (Author), Conte, Darryl (Author), Zender, Lars (Author), Wang, Xin Wei (Author), Thorgeirsson, Snorri (Author), Weng, Zhiping (Author), Xue, Wen (Author)
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Harvard University- (Contributor), Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier BV, 2019-08-13T15:18:45Z.
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