Poly(glycoamidoamine) brush nanomaterials for systemic siRNA delivery in vivo

Poly(glycoamidoamine) brush nanomaterials for systemic siRNA delivery in vivo

Delivery is the key challenge for siRNA based therapeutics. Here, we report the development of new poly(glycoamidoamine) brush nanomaterials for efficient siRNA delivery. GluN4C10 polymer brush nanoparticles, a lead material, demonstrated significantly improved delivery efficiency for siRNA against...

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Bibliographic Details
Main Authors: Luo, X. (Author), Wang, Wei (Author), Dorkin, Joseph Robert (Author), Veiseh, Omid (Author), Chang, Pyung-Hun (Author), Abutbul-Ionita, I. (Author), Danino, D. (Author), Langer, Robert S (Author), Anderson, Daniel Griffith (Author), Dong, Y. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Royal Society of Chemistry (RSC), 2019-08-13T15:55:27Z.
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