Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37-N¹)-Methyltransferase (TrmD) by Restructuring the Active Site with a Tyrosine-Flipping Mechanism

Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37-N¹)-Methyltransferase (TrmD) by Restructuring the Active Site with a Tyrosine-Flipping Mechanism

Among the >120 modified ribonucleosides in the prokaryotic epitranscriptome, many tRNA modifications are critical to bacterial survival, which makes their synthetic enzymes ideal targets for antibiotic development. Here we performed a structure-based design of inhibitors of tRNA-(N1G37) methyltra...

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Main Authors: Zhong, Wenhe (Author), Pasunooti, Kalyan Kumar (Author), Balamkundu, Seetharamsing (Author), Wong, Yee Hwa (Author), Nah, Qianhui (Author), Gadi, Vinod (Author), Gnanakalai, Shanmugavel (Author), Chionh, Yok Hian (Author), McBee, Megan E. (Author), Gopal, Pooja (Author), Lim, Siau Hoi (Author), Olivier, Nelson (Author), Buurman, Ed T. (Author), Dick, Thomas (Author), Liu, Chuan Fa (Author), Lescar, Julien (Author), Dedon, Peter C (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor)
Format: Article
Language:English
Published: American Chemical Society (ACS), 2019-09-23T17:34:10Z.
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