Site-Selective Cysteine-Cyclooctyne Conjugation

Site-Selective Cysteine-Cyclooctyne Conjugation

We report a site-selective cysteine-cyclooctyne conjugation reaction between a seven-residue peptide tag (DBCO-tag, Leu-Cys-Tyr-Pro-Trp-Val-Tyr) at the N or C terminus of a peptide or protein and various aza-dibenzocyclooctyne (DBCO) reagents. Compared to a cysteine peptide control, the DBCO-tag inc...

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Bibliographic Details
Main Authors: Zhang, Chi (Author), Dai, Peng (Author), Vinogradov, Alexander A. (Author), Gates, Zachary P (Author), Pentelute, Bradley L. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Chemistry (Contributor)
Format: Article
Language:English
Published: Wiley, 2020-01-21T22:20:04Z.
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