Perfluoroaryl Bicyclic Cell-Penetrating Peptides for Delivery of Antisense Oligonucleotides

Exon-skipping antisense oligonucleotides are effective treatments for genetic diseases, yet exon-skipping activity requires that these macromolecules reach the nucleus. While cell-penetrating peptides can improve delivery, proteolytic instability often limits efficacy. It is hypothesized that the bi...

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Bibliographic Details
Main Authors: Wolfe, Justin (Author), Fadzen, Colin M. (Author), Holden, Rebecca Lynn (Author), Yao, Monica (Author), Hanson, Gunnar J. (Author), Pentelute, Bradley L. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Chemistry (Contributor)
Format: Article
Language:English
Published: Wiley, 2020-01-22T16:30:22Z.
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