A Method for Selective Depletion of Zn(II) Ions from Complex Biological Media and Evaluation of Cellular Consequences of Zn(II) Deficiency

A Method for Selective Depletion of Zn(II) Ions from Complex Biological Media and Evaluation of Cellular Consequences of Zn(II) Deficiency

We describe the preparation, evaluation, and application of an S100A12 protein-conjugated solid support, hereafter the "A12-resin", that can remove 99% of Zn(II) from complex biological solutions without significantly perturbing the concentrations of other metal ions. The A12-resin can be...

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Bibliographic Details
Main Authors: Richardson, Christopher E. R. (Author), Cunden, Lisa Stephanie (Author), Butty, Vincent L G (Author), Nolan, Elizabeth Marie (Author), Lippard, Stephen J. (Author), Shoulders, Matthew D. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Chemistry (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor)
Format: Article
Language:English
Published: American Chemical Society (ACS), 2020-01-23T20:05:47Z.
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