A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade

Immune checkpoint inhibitors (ICIs) produce durable responses in some melanoma patients, but many patients derive no clinical benefit, and the molecular underpinnings of such resistance remain elusive. Here, we leveraged single-cell RNA sequencing (scRNA-seq) from 33 melanoma tumors and computationa...

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Main Authors: Jerby-Arnon, Livnat (Author), Shah, Parin (Author), Cuoco, Michael S. (Author), Rodman, Christopher (Author), Su, Mei-Ju (Author), Melms, Johannes C. (Author), Leeson, Rachel (Author), Kanodia, Abhay (Author), Mei, Shaolin (Author), Lin, Jia-Ren (Author), Wang, Shu (Author), Rabasha, Bokang (Author), Liu, David (Author), Zhang, Gao (Author), Margolais, Claire (Author), Ashenberg, Orr (Author), Ott, Patrick A. (Author), Buchbinder, Elizabeth I. (Author), Haq, Rizwan (Author), Hodi, F. Stephen (Author), Boland, Genevieve M. (Author), Sullivan, Ryan J. (Author), Frederick, Dennie T. (Author), Miao, Benchun (Author), Moll, Tabea (Author), Flaherty, Keith T. (Author), Herlyn, Meenhard (Author), Jenkins, Russell W. (Author), Thummalapalli, Rohit (Author), Kowalczyk, Monika S. (Author), Cañadas, Israel (Author), Schilling, Bastian (Author), Cartwright, Adam N.R (Author), Luoma, Adrienne M. (Author), Malu, Shruti (Author), Hwu, Patrick (Author), Bernatchez, Chantale (Author), Forget, Marie-Andrée (Author), Barbie, David A. (Author), Shalek, Alex K. (Author), Tirosh, Itay (Author), Sorger, Peter K. (Author), Wucherpfennig, Kai (Author), Van Allen, Eliezer M. (Author), Schadendorf, Dirk (Author), Johnson, Bruce E. (Author), Rotem, Asaf (Author), Rozenblatt-Rosen, Orit (Author), Garraway, Levi A. (Author), Yoon, Charles H. (Author), Izar, Benjamin (Author), Regev, Aviv (Author)
Other Authors: Broad Institute of MIT and Harvard (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Ludwig Center for Molecular Oncology (Massachusetts Institute of Technology) (Contributor)
Format: Article
Language:English
Published: Elsevier BV, 2020-01-23T21:26:00Z.
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