Affinity-based capture and identification of protein effectors of the growth regulator ppGpp

Affinity-based capture and identification of protein effectors of the growth regulator ppGpp

The nucleotide ppGpp is a highly conserved regulatory molecule in bacteria that helps tune growth rate to nutrient availability. Despite decades of study, how ppGpp regulates growth remains poorly understood. Here, we developed and validated a capture-compound mass spectrometry approach that identif...

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Bibliographic Details
Main Authors: Wang, Boyuan (Author), Dai, Peng (Author), Ding, David (Author), Del Rosario, Amanda M (Author), Grant, Robert A (Author), Pentelute, Bradley L. (Author), Laub, Michael T (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Massachusetts Institute of Technology. Center for Environmental Health Sciences (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Springer Science and Business Media LLC, 2020-01-23T23:19:23Z.
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