Pol II phosphorylation regulates a switch between transcriptional and splicing condensates

Pol II phosphorylation regulates a switch between transcriptional and splicing condensates

The synthesis of pre-mRNA by RNA polymerase II (Pol II) involves the formation of a transcription initiation complex, and a transition to an elongation complex1-4. The large subunit of Pol II contains an intrinsically disordered C-terminal domain that is phosphorylated by cyclin-dependent kinases du...

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Main Authors: Manteiga, John Colonnese (Author), Spille, Jan Hendrik (Author), Afeyan, Lena K. (Author), Zamudio Montes de Oca, Alicia (Author), Shrinivas, Krishna (Author), Cisse, Ibrahim I (Author), Sharp, Phillip A. (Author), Young, Richard A. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Physics (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor)
Format: Article
Language:English
Published: Springer Science and Business Media LLC, 2020-03-26T12:17:58Z.
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