Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains

Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains

Gene expression is controlled by transcription factors (TFs) that consist of DNA-binding domains (DBDs) and activation domains (ADs). The DBDs have been well characterized, but little is known about the mechanisms by which ADs effect gene activation. Here, we report that diverse ADs form phase-separ...

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Main Authors: Klein, Isaac A. (Author), Sabari, Benjamin R. (Author), Dall'Agnese, Alessandra (Author), Coffey, Eliot L. (Author), Zamudio, Alicia V. (Author), Manteiga, John C. (Author), Hannett, Nancy M. (Author), Abraham, Brian J. (Author), Afeyan, Lena K. (Author), Guo, Yang E. (Author), Schuijers, Jurian (Author), Lee, Tong Ihn (Author), Taatjes, Dylan J. (Author), Young, Richard A. (Author), Shrinivas, Krishna,Ph. D.Massachusetts Institute of Technology (Author), Li, Charles H. (Author)
Other Authors: Whitehead Institute for Biomedical Research (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor)
Format: Article
Language:English
Published: Elsevier BV, 2020-04-14T14:16:14Z.
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