Hierarchical Organization Endows the Kinase Domain with Regulatory Plasticity

Hierarchical Organization Endows the Kinase Domain with Regulatory Plasticity

The functional diversity of kinases enables specificity in cellular signal transduction. Yet how more than 500 members of the human kinome specifically receive regulatory inputs and convey information to appropriate substrates-all while using the common signaling output of phosphorylation-remains en...

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Bibliographic Details
Main Authors: Creixell, Pau (Author), Pandey, Jai P. (Author), Creixell, Marc (Author), Pincus, David (Author), Yaffe, Michael B. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Whitehead Institute for Biomedical Research (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier BV, 2020-04-15T13:00:15Z.
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