Nutrient mTORC1 signaling underpins regulatory T cell control of immune tolerance

Foxp3+ regulatory T (T reg) cells are pivotal regulators of immune tolerance, with T cell receptor (TCR)-driven activated T reg (aT reg) cells playing a central role; yet how TCR signaling propagates to control aT reg cell responses remains poorly understood. Here we show that TCR signaling induces...

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Bibliographic Details
Main Authors: Efeyan, Alejo (Author), Sabatini, David M. (Author)
Other Authors: Whitehead Institute for Biomedical Research (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Rockefeller University Press, 2020-04-16T13:20:55Z.
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