DEPTOR modulates activation responses in CD4+ T cells and enhances immunoregulation following transplantation

DEPTOR is an evolutionarily conserved cell-intrinsic binding partner of mTOR that functions as a negative regulator of signaling responses. In this study, we show that DEPTOR is expressed within CD4 + T cells, and we observed that its relative level of expression modulates differentiation as well as...

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Bibliographic Details
Main Author: Sabatini, David M. (Author)
Other Authors: Whitehead Institute for Biomedical Research (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor)
Format: Article
Language:English
Published: Wiley, 2020-04-16T14:56:39Z.
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