SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism

SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism

One-carbon metabolism generates the one-carbon units required to synthesize many critical metabolites, including nucleotides. The pathway has cytosolic and mitochondrial branches, and a key step is the entry, through an unknown mechanism, of serine into mitochondria, where it is converted into glyci...

Full description

Bibliographic Details
Main Authors: Kory, Nora (Author), Wyant, Gregory A. (Author), Prakash, Gyan (Author), De Bos, Jelmi uit (Author), Pacold, Michael E. (Author), Chan, Sze Ham (Author), Lewis, Caroline A. (Author), Wang, Tim (Author), Keys, Heather R. (Author), Sabatini, David M. (Author)
Other Authors: Whitehead Institute for Biomedical Research (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS), 2020-04-16T15:35:21Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items