Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death

Cholesterol is essential for cells to grow and proliferate. Normal mammalian cells meet their need for cholesterol through its uptake or de novo synthesis1, but the extent to which cancer cells rely on each of these pathways remains poorly understood. Here, using a competitive proliferation assay on...

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Bibliographic Details
Main Authors: Freinkman, Elizaveta (Author), Chan, Sze Ham (Author), Lewis, Caroline (Author), Sabatini, David M. (Author)
Other Authors: Whitehead Institute for Biomedical Research (Contributor)
Format: Article
Language:English
Published: Springer Science and Business Media LLC, 2020-04-21T13:51:13Z.
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