Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death
Cholesterol is essential for cells to grow and proliferate. Normal mammalian cells meet their need for cholesterol through its uptake or de novo synthesis1, but the extent to which cancer cells rely on each of these pathways remains poorly understood. Here, using a competitive proliferation assay on...
Main Authors: | Freinkman, Elizaveta (Author), Chan, Sze Ham (Author), Lewis, Caroline (Author), Sabatini, David M. (Author) |
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Other Authors: | Whitehead Institute for Biomedical Research (Contributor) |
Format: | Article |
Language: | English |
Published: |
Springer Science and Business Media LLC,
2020-04-21T13:51:13Z.
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Subjects: | |
Online Access: | Get fulltext |
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