Identification of the minimal bacterial 2'-deoxy-7-amido-7-deazaguanine synthesis machinery

The 7-deazapurine derivatives, 2'-deoxy-7-cyano-7-deazaguanosine (dPreQ0) and 2'-deoxy-7-amido-7-deazaguanosine (dADG) are recently discovered DNA modifications encoded by the dpd cluster found in a diverse set of bacteria. Here we identify the genes required for the formation of dPreQ0 an...

Full description

Bibliographic Details
Main Authors: Valera, Jacqueline Gamboa (Author), Hu, Jennifer (Author), Hillebrand, Roman (Author), Dedon, Peter C. (Author)
Format: Article
Language:English
Published: Wiley, 2020-04-23T14:12:45Z.
Subjects:
Online Access:Get fulltext