Exploration of icariin analog structure space reveals key features driving potent inhibition of human phosphodiesterase-5
The natural product icariin inhibits human phosphodiesterase-5 (PDE5) and represents a unique pharmacophore for treating erectile dysfunction, pulmonary hypertension, and other diseases. In this study, we explore the available icariin-derived chemical scaffolds through medicinal chemistry to develop...
| Main Authors: | , , , |
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| Other Authors: | , |
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS),
2020-04-29T16:45:49Z.
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| Subjects: | |
| Online Access: | Get fulltext |