Cytosolic Aspartate Availability Determines Cell Survival When Glutamine Is Limiting

Cytosolic Aspartate Availability Determines Cell Survival When Glutamine Is Limiting

Mitochondrial function is important for aspartate biosynthesis in proliferating cells. Here, we show that mitochondrial aspartate export via the aspartate-glutamate carrier 1 (AGC1) supports cell proliferation and cellular redox homeostasis. Insufficient cytosolic aspartate delivery leads to cell de...

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Bibliographic Details
Main Authors: Alkan, H. Furkan (Author), Luengo, Alba (Author), Lau, Allison N. (Author), Lewis, Caroline A. (Author), Vander Heiden, Matthew G. (Author)
Other Authors: Whitehead Institute for Biomedical Research (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier BV, 2020-04-29T17:46:38Z.
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